Starvation and Pseudo-Starvation as Drivers of Cancer Metastasis through Translation Reprogramming

Translation form of depot fat in starvation.

Gordon et all-3 suggested that the transport of depot fat to the site of utilization probably takes place in the form of free fatty acid (unesterified fatty acid). Under both normal and abnormal circumstances, the amount of free fatty acid is very small in the serum and liver occupying only 1/4-1/5 of triglyceride or phospholipid. The portion derived from dietary fat is transported mainly in th...

PEPCK in cancer cell starvation.

Nutrient and oxygen (O2) deprivation are frequent in solid cancers. Angiogenesis is activated early in cancer growth, however, the newly formed vascular network is aberrant and shows irregular blood flow [1]. Moreover, cancer cells themselves contribute to gradients for nutrients like glucose due to high consumption. The concentration of glucose was estimated to be on average 3 to 10 times lowe...

Nanoscale gold pillars strengthened through dislocation starvation

It has been known for more than half a century that crystals can be made stronger by introducing defects into them, i.e., by strain-hardening. As the number of defects increases, their movement and multiplication is impeded, thus strengthening the material. In the present work we show hardening by dislocation starvation, a fundamentally different strengthening mechanism based on the elimination...

Starvation induces genomic rearrangements and starvation-resilient phenotypes in yeast.

Evolution has shaped a wide variety of genomes across eukaryotic taxa. However, the forces that shape the genomes are generally unknown. Because organisms in nature commonly experience prolonged periods of nutrient depletion, we posit that diverse demographic, physiological, and genomic responses to starvation can occur. To test for these possibilities, we subjected replicate yeast populations ...

Chronic Starvation